Control of Vitamin B 6 Biosynthesis in Escherichia coli
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چکیده
منابع مشابه
Control of vitamin B 6 biosynthesis in Escherichia coli.
Pyridoxineless mutants of Escherichia coli B which specifically require pyridoxal or pyridoxamine for growth can be divided into classes according to their growth responses in enriched media. Members of the slowest growing class synthesize vitamin B(6) at the fastest rates when starved for pyridoxal in glycerol minimal medium. After 80 min of synthesis at 4 x 10(-10) moles of vitamin B(6) per m...
متن کاملRole of vitamin B 6 biosynthetic rate in the study of vitamin B 6 synthesis in Escherichia coli.
Nutritional auxotrophs of Escherichia coli synthesize vitamin B(6) compounds at a rate of 1 x 10(-10) to 2 x 10(-10) moles per hr per mg (dry weight) of cells when they are suspended in minimal medium lacking their required nutrients. A few auxotrophs have been found to stop or reduce vitamin B(6) synthesis during such an experiment. These include thiamineless, citrate synthaseless, and pyridox...
متن کاملControl of Pyridoxine Biosynthesis in Escherichia Coli.
Dempsey, Walter B. (University of Florida, Gainesville). Control of pyridoxine biosynthesis in Escherichia coli J. Bacteriol. 90:431-437. 1965.-The total pyridoxine in a culture of exponentially growing Escherichia coli was 3.6 x 10(-10) moles per mg of dry cells. One-fourth of this total was present in the medium, and was at least 90% pyridoxal 5'-phosphate. Both pyridoxol and pyridoxal, when ...
متن کاملThe effects of 6-mercaptopurine on biosynthesis in Escherichia coli.
The purine analogue, 6-mercaptopurine (6-MP) (l), has been the subject of considerable study, but the mechanisms of its actions are still not clear. This drug inhibits the proliferation of acute and chronic myelocytic leucemias (2) and the growth of bacteria (3). It interferes with the utilization of formate for nucleic acid synthesis (4) and suppresses the formation of adaptive enzymes (5). Ho...
متن کاملProbing the heterologous metabolism supporting 6‐deoxyerythronolide B biosynthesis in Escherichia coli
Heterologous biosynthesis offers a new way to capture the medicinal properties presented by complex natural products. In this study, production of 6-deoxyerythronolide B (6dEB), the polyketide precursor to the antibiotic erythromycin, was used to probe the heterologous pathways needed for Escherichia coli-derived biosynthesis. More specifically, the heterologous proteins responsible for 6dEB pr...
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ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 1971
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.108.1.415-421.1971